Taking vitamin D in Western culture has quickly become an ‘if some is good, more is better’ game of taking chances on mega-dose supplements.
But there are problems. Major problems, that no-one is talking about. Till now.
Problem #1 — The deficiency ranges:
What even classifies vitamin D deficiency? The answer varies, in short, It depends on who you talk to. Some of the biggest authorities wildly disagree:
The Vitamin D Council definition :
Deficient: 0–40 ng/ml
Sufficient: 40–80 ng/ml
High normal: 80–100 ng/ml
The Endocrine Society definition :
Deficiency ≤ 20 ng/ml
Insufficiency = 20–29 ng/ml
The Institute of Medicine definition :
Risk/deficiency ≤12 ng/ml
Risk/insufficiency = 12–20 ng/ml
Sufficient = 20 ng/ml
So depending on your medical authorities, you could be considered deficient and sufficient at the same time.
Problem #2 — Reasons vitamin D can be low that don’t stem from not enough vitamin D:
The following summarizes some of the reasons vitamin D 25(OH)D (storage form of vitamin D) can be low that do not indicate you need to supplement with vitamin D3:
- Low magnesium 
- Low boron 
- Low vitamin C 
- Inflammation/infection (in these cases the ‘storage form’ of vitamin D is often low, but the active form is high (which is not typically tested). As someone who tests gut bacteria, I can tell you this is extremely common. 
- Low glutathione 
- Glyphosate (i.e. Roundup, GMOs, non-organic food) 
- Favorable gut bacteria conditions (i.e. healthy guts) 
I believe these reasons are why so many people are supplementing only to *not see* levels easily come up. They are hitting the wrong nail with their hammer.
Additionally, automatically sprinkling ‘high dose vitamin D supplements’ on everyone who has low serum D is NOT the answer and can do harm in some cases. Bringing us to the next problem…
Problem #3 —The side effects:
Mega-dosing any vitamin supplement can have side effects, but this is especially true for fat soluble vitamins that are stored in the body and cannot quickly leave. Vitamin D is stored in your fat cells and subject to toxicity. You can’t just pee it out when you get too much.
Vitamin D has well-known side effects and is used as a potent rat poison for those very reasons.
According to a 2022 report entitled: Vitamin D toxicity due to self-prescription: A case report, the general population is unaware of the risks: “People are taking vitamin D orally or intramuscularly in mega doses as a supplement without adequate medical monitoring and indication. This leads to vitamin D toxicity causing hypercalcemia, acute kidney injury, and altered sensorium. Vitamin D is fat-soluble and remains in the body for long time and is released slowly. People are not aware of this phenomenon.” 
A few important markers for vitamin D supplementation are as follows:
- The upper limit is 4,000iu per the NIH 
- The Endocrine Society recommends 1,500-2,000iu
- Some research says adverse effects can start at 3,800iu 
- Personally I see anything over 1,000-2,000iu impacting hair tissue mineral levels in the following ways:
- increased calcium levels (calcium slows things down in the body)
- decreased potassium levels
- This disrupts mineral patterns in a significant way and can impact your thyroid’s ability to do its job. A disrupted calcium:potassium ratio can look like:
- brain fog
- low body temperature
- blood sugar issues (hypoglycemia)
As someone who tests mineral levels using hair tissue mineral analysis on clients worldwide, I see calcium levels creep up in a dose-dependent manner in relation to vitamin D supplement intake (dose and duration determine with how elevated calcium gets), along with other non-vitality supporting mineral changes.
Problem #4: High doses were not intended to be taken orally
I never see high calcium levels from people getting vitamin D from the sun. It’s always supplement sources. What does that tell us?
Vitamin D from the sun and oral supplements do not act identically in the body.
It is also very hard to find high amounts of oral vitamin D in nature. Nearly impossible to get close to ‘supplement levels’ consistently.
For instance, one of the top food sources for vitamin D is wild salmon. You’d have to eat 1 pound of salmon every day to get approximately 2,384iu of vitamin D from food. If you tried doing that every day, you’d put yourself at risk of mercury toxicity pretty quickly.
This is common in nature. It’s hard to find large amounts of fat soluble vitamins (those being A, D, E & K) that are stored in the body for a reason.
Some may think nature’s ‘trying to kill you,’ while I believe nature is communicating a message and trying to keep you alive.
So the bigger question is — what is nature trying to tell you? Perhaps vitamin D is meant to be part of chemical reaction that happens on the skin and largely not absorbed through the oral route (without risking side effects long term). Trying to ‘outsmart’ nature with supplement after supplement never works in the long term from what I’ve seen in my nutrition practice.
Supplement wisely, and more importantly — don’t forget to let your control how much vitamin D it needs to make from getting adequate sun exposure (the superior source of vitamin D). Remember, it’s fat soluble, so your body can store it for those dark winter months.
Some vitamin D is good. More is not better. Testing and thinking critically before taking high dosages is smart.